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16 , 66346647 (1996) Mayer, M
In 2020, a related study (28) demonstrated that overexpression of miR-140-3p inhibited the proliferation of human cervical cancer cells by targeting down-regulation of RRM2 inducing cell cycle arrest and early apoptosis, while decreasing BCL-2 protein levels and inducing a significant increase in BAX and caspase-3 protein levels
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Certain drugs, such as oxfenicine and perhexiline, have been observed to induce the expression of pivotal mitochondrial proteins implicated in cardiac energy metabolism [128]
These metabolic features of NRF2 addiction status provide clues for novel therapeutic strategies to target NRF2-addicted cancer cells
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