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By contrast, a very recent human study employing 2000 mg NR daily supplementation, which is approximately 23 times lower in concentration compared to the animal studies, could not reproduce the positive effects on insulin sensitivity and whole-body glucose metabolism in obese insulin resistant men [26]

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27.Malur A, Baker AD, McCoy AJ, et al

7,13-16 Overall, there is strong evidence indicating that hs-CRP is associated with cardiovascular disease, although the magnitude of these associations may be confounded by established cardiovascular risk factors