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It took over 40 days to get a message back to the East Coast of the United States and often over 200300 days to get new supplies shipped in by sailing ships

H., Huitema, A

N Engl J Med 2017

Experimentally, the released active agent is optionally fitted to the Korsmeyer-Peppas equation Q/Q =kt n +b where Q is the amount of active agent released at time t, Q is the overall released amount of active agent, k is a release constant of the nth order, n is a dimensionless number related to the dissolution mechanism, and b is the axis intercept, characterizing the initial burst release mechanism wherein n=1 characterizes an erosion controlled mechanism

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