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Proceedings of the National Academy of Sciences of the United States of America, 109, 1355513560

Normally, NAPQI is rapidly de-toxified by conjugation with glutathione, but the pathway can become saturated as a result of overdose, combination with alcohol, or in individuals with polymorphisms in the P450 metabolizing enzymes

These include small molecules such as M1 fusion promoter, and Mdivi1, a fission inhibitor that proved effective in several in vivo studies [161,162,163,164]

Interplay between the unfolded protein response and reactive oxygen species: A dynamic duo

Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bhr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Btzel K, Groschup M, Kretzschmar H, Griesinger C, Giese A (2013) Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinsons disease

How MOTS-c Works MOTS-c is fundamentally different from most peptides