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Our previous data also suggests that maternal SE impairs brain mitochondrial levels of oxidative phosphorylation (OXPHOS) complexes in male offspring with reduced endogenous antioxidant capacity from birth (Chan et al., Furthermore, as SE offspring have reduced brain antioxidants and increased cellular oxidative damage (Chan et al., 2015) and can provide neuroprotection by elevating brain antioxidant capacity in aging rats (Juliet et al., Materials and Methods Animals The animal experiments were approved by the Animal Care and Ethics Committee at the University of Technology Sydney (ACEC#2011-313A)

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doi:10.1016/j.pneurobio.2005.04.003

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Antidepressants and synaptic plasticity Chronic administration of typical antidepressants that block the reuptake and breakdown of monoamines increase synaptic plasticity at several levels including increased birth of new neurons in the adult hippocampus, increased neurotrophic factor expression, and regulation of synapse formation 10,132,133

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