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The diagnosis of BPI was made by a neurologist

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Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]

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These studies also suggest that its action may go beyond its antioxidant capacity, as melatonin has demonstrated other mechanisms of action in inflammatory, apoptotic, and oxidative system stability [12,13,14,15,16,17,18,19,20,21]