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One potential cause is when antibiotics or antimicrobials kill spirochetes, they break apart and release inflammatory substances such as cytokines into the bloodstream, triggering a strong immune response

Goetz RM, Thatte HS, Prabhakar P, Cho MR, Michel T, Golan DE: Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase

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4.1.4 Ferroportin (FPN) FPN is mammalian cells sole iron exporter, pivotal in maintaining intracellular iron homeostasis

Am J Gastroenterol 2010;105:229-230