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Methods Search strategy and selection criteria The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD420251088025

doi:10.1017/S1461145713001685 McCoy, Alene T et al

From telomere maintenance to melatonin regulation, antioxidant defenses, and even tumor suppression, Epitalon presents a compelling narrative backed by molecular evidence

In this regard, a proposed strategy for studying the epigenetic mechanisms of peptide regulation of gene expression can be a functional analysis of peptideDNA binding regions, as well as a comparison of peptide structures with functional domains of regulatory molecules (transcription factors, DNA/RNA-binding proteins, and ncRNA) [174], directly or indirectly related to the regulation of gene expression in AD and other neuropathology

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Clinical signs include anorexia, recumbency, lethargy, muscle spasm of the head and neck (opisthotonos), dropped head, convulsion, sweet smelling breath, apparent blindness, bloat, teeth grinding, and frothy salivation (Vasava et al., 2016)