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Mild liver stress : less than oral steroids but not zero, particularly with more potent compounds at higher doses

These may include medications, surgery, lifestyle changes, and other procedures

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de Monchaux Oliveira C, Morael J, Guille A, Amadieu C, Vancassel S, Gaudout D, Capuron L, Pourtau L, Castanon N (2023) Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice

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Stay hydrated: Drinking plenty of water helps reduce bloating and fatigue