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This suggests that oxidative stress exerts a dual influence on insulin secretion: moderate levels of oxidative stress may enhance insulin secretion, whereas excessive oxidative damage impairs the compensatory capacity of insulin secretion

Ferroptosis and NRF2: An emerging battlefield in the neurodegeneration of Alzheimers disease
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doi: 10.1207/S15327914NC3701_13

If you plateau at a sub-maximal dose, escalation is the logical next step

Nerve conduction studies and electromyography (EMG): detect alterations in nerve conduction
