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In the next step, a second equivalent of GSH reacts with the glutathionylated intermediate to form the stable product GSSG, and this allows the release of the reduced selenium or cystine for the next catalytic cycle (see Figure 4 for an example of GPX4 oxidoreductase mechanism)

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Lochhead J.J., McCaffrey G., Quigley C.E., Finch J., DeMarco K.M., Nametz N., Davis T.P

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Risk of lung cancer associated with domestic use of coal in xuanwei, china: retrospective cohort study

Mrp8 is known to efflux dehydropiandrosteron-3-sulfate, an endogenous precursor of many sex hormones (Chen et al., 2005b

or, when R 6c is independently C 1 -C 4 alkyl, the C 1 -C 4 alkyl is independently methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl