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Recent studies evaluating repeated dosing of the mGlu 2 PAM AZD8529 demonstrated that this PAM persistently suppressed nicotine self-administration in rats (Li et al., 2016) and squirrel monkeys (Justinova et al., 2015), providing substantial support for the hypothesis that PAMs may possess an advantage over agonists with regards to tolerance

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INTRODUCTION Harvey Cushing proposed in 1912 in his monograph The Pituitary Gland the existence of a hormone of growth and was thereby among the first to indicate that the primary action of growth hormone (GH) was to control and promote skeletal growth

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Next, 18 l of the soluble polar metabolite supernatant was transferred to sample vials for analysis by LCMS as previously described 4,28