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doi: 10.3389/fendo.2023.1234563 216 JiangZWangHQiGJiangCChenKYanZ

65 Macrophages can be categorized into M1 (classically activated) macrophages that contribute to tissue destruction and secrete pro-inflammatory factors and M2 (alternatively activated) macrophages that produce anti-inflammatory factors

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Therefore, what may seem to be inconsistency in the literature, may actually indicate variations of dose, tumor genotype, microenvironment, and formulation, as opposed to the actual inconsistency of the mechanism [266]

The abnormal architecture of the tumor vasculature results in hypoxia, immune exclusion, and poor drug delivery, thus promoting therapeutic resistance (128)