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NRF2 activation plays a key role in cellular repair during sleep by upregulating antioxidant enzymes (SOD, catalase, HO-1), reducing oxidative damage, and promoting mitochondrial biogenesis, which are critical for neuronal recovery and energy homeostasis

Carracedo, Klotho prevents translocation of NFB

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Significant OE and KD of PHACTR1 were confirmed within the resulting transcriptomic dataset, identifying PHACTR1 as the most significantly up- and down-regulated gene in their respective cell lines when compared to scrm ctrl cells (Fig

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The classical NF-B pathway is activated within minutes after exposure to proinflammatory signals, and involves TGF- associated kinase 1 (TAK1)-mediated activation of the IKK complex (consisting of catalytic (IKK and IKK) and regulatory (IKK) subunits), which mediates the phosphorylation and subsequent degradation of IB (an IB family protein), leading to the nuclear translocation of the NF-B heterodimer RelA/p50