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These include mitochondrial disorders, multiple system atrophy, ataxia due to APTX mutations, mutations in ETFDH , and Parkinsons disease

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

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For instance, in mdx mice (a model of dystrophinopathy), an improved calcium handling resulting in lower intracellular calcium concentrations and enhanced cell survival have been shown in cultured cells [50]

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The NLRP3 inflammasome serves as a double-edged sword in carcinogenesis, mediating protective immune responses while driving pathological inflammation when dysregulated (Zhang et al., 2021)