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Nevertheless, double heterozygote MTHFR 677 C/T and 1298 A/C results in the lowest MTHFR activity

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After 4 weeks of cobalamin treatment, there appeared to be a trend towards lower concentrations for both these metabolites

Some researchers have conceptually explored combining both strategies for potentially synergistic effects on intracellular NAD+ levels, though no published data exists for this specific combination