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29,37 Norrin protein can also bind to Frizzled class receptor 4 (FZD4) and LRP5/6 to form a ternary complex and promote the downstream signal transmission of Wnt/-catenin

This work was supported by the Project of the Jilin Science and Technology Development Program(20220401085YY)

Addressing current challenges will help translate promising findings into effective, personalized treatments

Salvage bevacizumab (rhuMAB VEGF)-based therapy after multiple prior cytotoxic regimens in advanced refractory epithelial ovarian cancer

found that the combination therapy of glucocorticoids, SAM, and IFN- is possibly useful for CHB patients

This findings are consistent with study of Song et al