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These results imply that GCLC, GSS and SLC7A11 are the potential regulatory targets involved in the VRK2-driven metabolic synthesis pathway of GSH

Of note, whereas drug adverse effects may emerge early because of the sudden exposure of the body to a new substance, adverse effects tend to be clearly present only when a critical threshold, usually related to blood level, is reached

The enzyme myo-inositol oxygenase, a proximal tubular enzyme that exacerbates cellular redox injury, played a key role in cisplatin-induced ferroptosis.59 However, discrepant results were reported in cultured tubular cells

L-carnitine also increased the hepatic expression of mTOR in the feeding state

mRNA-based cancer therapeutics

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