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Diagnosing pathological fatigue necessitates the significant presence of fatigue, reduced energy, and a disproportionate need for rest relative to activity levels

Naderi, A., Chia, K

Factor H-related protein 1, which promotes complement activation by the competitive inhibition of factor H binding to specific surfaces and immune proteins, was found at high concentrations to compete with factor H for CRP binding, revealing possible complement deregulation on this ligand [129]

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