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Further, alteration in its DNA methylation levels, assessed by measuring the CpG islands from the Exon IV of the BDNF gene, was shown to be associated with bipolar disorder and major depression (Kundakovic et al., 2015)
Therefore, it is necessary to further explore the precise metformin doses required to change the AMP/ATP ratio and activate AMPK, in order to fully understand the effect of metformin on complex I (Table 4)
doi: 10.1097/CCM.0b013e3181800387
Epub 2013/03/08
Krens, S.F.G, Kaufmann, W., Gyoergy, A., Casano, A.M., Siekhaus D.E
doi: 10.1016/j.cell.2015.01.043
