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Another characteristic of PD is the loss of dopaminergic neurons in the substantia nigra and the subsequent decrease in dopamine levels in the substantia nigra striatum

doi: 10.1097/01.WCB.0000053472.41007.F9 16 DuW.DengY.JiangR.TongL.LiR.JiangX

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Conversely, the increased export of 2-Oxoglutarate into the cytosol could augment the activity of Fe (II) 2-oxoglutarate (2OG)dependent oxygenases, enzymes that catalyze a variety of critical reactions including hydroxylation, halogenation, desaturation, and ring transformation

For the FM model, the animals were administered three consecutive days of subcutaneous (SC) injections of reserpine (1 mg/kg), which was dissolved in glacial acetic acid and then diluted with double-distilled water to a final concentration of 0.5% acetic acid, the dose adjusted to be injected in a volume of 1 mL/kg 49

J Trauma and Acute Care Surgery