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18 The different biological activities induced by the components of SASP suggest that it may interact with local and surrounding cells, and constitutes a mechanism to regulate microenvironment, which could be either beneficial or deleterious, depending on the secretion factors, site (cell types), duration (acute or chronic), and secretion-induced stimuli

Furthermore, HIF-1 downregulation was observed, concurrent with decreased expression of MMP-2 and MMP-9, which contribute to inflammation (240)

Proc Natl Acad Sci (2010) 107(25):1130712

2015), gene therapy using AAV vectors to deliver glutamate decarboxylase (GAD) into the STN has been introduced (Fig

This makes it easy for researchers to get their questions answered

Shi Q, Duvic M, Osei JS, et al