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GPX4 responds to various tissue injuries by inhibiting different cell death pathways, such as apoptosis, pyroptosis, and necroptosis (Ran et al., 2004)

A well-functioning MTHFR enzyme helps recycle homocysteine into methionine, an important building block for proteins

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These gender-specific effects may be important for the side effects of ibuprofen (such as increased risk of stroke) and more research is needed to investigate this possibility
