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Effect of the antioxidant alpha-lipoic acid on apoptosis in human umbilical vein endothelial cells induced by high glucose

Ultimately, melatonin induces widespread changes in expression of genes encoding phytohormone signaling components, transcription factors, and ROS scavenging enzymes, which has led to the suggestion that it plays a central role as an endogenous plant antioxidant (Hardeland 2016)

The process begins with the extracellular breakdown of GSH into its constituent amino acidsglutamate and cysteineby hepatic -glutamyl transferase (GGT), an enzyme present only on the external surfaces of cell types, such as those of the hepatobiliary tree and heart [87,88]

Transcribed image text: The stepwise mechanism below shows how glutathione (GSH) reacts with NAPQI

10.1038/s41578-021-00279-y 96 HferT.GernerI.Gundert-RemyU.LiebschM.SchulteA.SpielmannH.et al (2004)

In most cases, this translates into a 10% decrease in insulin requirements to maintain the same blood sugar levels