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Fingolimod, a sphingosine-1-phosphate receptor 1 modulator, regulates the immune response to UC by suppressing the AKT/mTOR pathway, thereby regulating the balance of proinflammatory cytokines and anti-inflammatory cytokines

Most treatments are limited to spinal axonal lesions and early asymptomatic periods due to the lack of suitable animal models and are hardly effective for CALD or progressive conditions

Inhibitors of ROS production have the potential of specificity, as drugs can be designed to inhibit specific ROS-generating systems

[DOI] [PubMed] [Google Scholar] 34.Giovannucci E, Pollak MN, Platz EA, Willett WC, Stampfer MJ, Majeed N, et al