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For example, a melanoma patient presenting with high TMB, robust tumor PD-L1 expression, and a biopsy showing abundant, functionally active CD8 T cells infiltrating tumor nests exemplifies a classic immune-hot profile, which strongly predicts a high potential for a profound initial response to immunotherapies such as ICIs [32, 390]

Access this article Similar content being viewed by others References Sundd P, Gladwin MT, Novelli EM (2019) Pathophysiology of sickle cell disease

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J Biol Chem 270:1814118146