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n=306 ALC, n=299 control), the pooled estimate favored ALC (SMD 1.38, 95% CI 2.41 to 0.34

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In direct comparisons of ALC with active drugs, ALC had fewer reported AEs, mostly CNS or GI, while comparator events reflected drug-specific profiles (eg., endocrine events with amisulpride)

The majority of research confirms that dosages between 500 mg and 3,000 mg daily are well-tolerated and effective

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