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The use of high levels of glutathione may lead to blood poisoning, and kidney failure and affect the liver

At a constant concentration of GSH with varying concentrations of MBB, the apparent K m , Vm and specific activity were respectively determined to be (8 to 9) molar
Accumulation of DNA damage in somatic cells has also been proposed to play a role in degenerative conditions such as accelerated aging, immune dysfunction, cardiovascular and neurodegenerative diseases

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Rojo AI, Pajares M, Garca-Yage AJ et al (2018) Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

Rheumatoid Arthritis can benefit from glutathione because it prevents apoptosis (programmed cell death) in healthy cells and induces apoptosis in rogue (disease-causing) cells, thus being a double-edged sword with synovial inflammation [4]
