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, Sahu, P

In future studies, it will be essential to understand how melatonin uses its anti-inflammatory and antioxidant properties to target inflammation and oxidative stress in the placenta

[DOI] [PubMed] [Google Scholar] Potters G., De Gara L., Asard H., Horemans N

As a central energy sensor, AMPK extends lifespan by promoting autophagy via mTOR inhibition and ULK1 activation, enhancing mitochondrial function through PGC-1/SIRT1 signaling and improving the NAD + /NADH balance, suppressing inflammatory responses via NF-B inhibition, and modulating stress resistance via the FOXO3/p53 pathways, thereby linking metabolic regulation to aging suppression 41

The association of systemic oxidative stress with insulin resistance: mechanistic insights from studies in Bartters and Gitelmans syndromes