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PSEN1 encodes Presenilin-1, the proteolytic subunit of -secretase, which is known to process APP (medlineplus.gov, 2021)

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This means that a peptide with a 2-hour half-life administered three times daily will reach steady-state within approximately 10 hours, while a peptide with a 7-day half-life like Semaglutide requires roughly 35 days to reach steady state with weekly dosing