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Glesatinib exhibits antitumor activity in lung cancer models and patients harboring MET exon 14 mutations and overcomes mutation-mediated resistance to type I MET inhibitors in nonclinical models

PARP1 promoter links cell cycle progression with adaptation to oxidative environment

This axis inhibits the presence of M1 macrophages, which are essential for antitumor immunity due to their pro-inflammatory and immune-activating properties

- Initial results in as early as 7-14 days

TMB substrate was added (100 L/well), and the plate was incubated for 20 min in the dark