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However, it is much less affected by changes in tyrosine levels, as TH is typically saturated with substrate
10.1097/FBP.0b013e32835a7c4d Behav
doi: 10.1016/j.semcancer.2020.03.004 51
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Furthermore, computational studies revealed that naringenin showed high binding affinity (9.5 kcal/mol) for collapsin response mediator protein2 (CRMP2), an ADrelated target, along with favorable BBB permeability, reinforcing its druglike properties (Lawal et al
