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Following a toxic dose of APAP, the conjugation pathways of the liver are overwhelmed and an increased proportion of APAP is metabolized by cytochrome (CYP) P450, predominantly CYP2E1, to the highly reactive metabolite NAPQI (Mitchell et al
doi: 10.3390/nu14204390
doi: 10.1111/j.1749-6632.1987.tb32915.x
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[DOI] [PubMed] 59.Abou-Alfa GK, Capanu M, OReilly EM, Ma J, Chou JF, Gansukh B, et al
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