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Lauroylcarnitine (C12-carnitine) can inhibit AMPK and secrete proinflammatory cytokines to promote the polarization of bone marrow-derived macrophages to the pro-inflammatory M1 phenotype [57]

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The differentiation of MSCs toward the osteogenic lineage is tightly controlled by different molecular factors, including the bone morphogenic proteins (BMPs) [95, 96], and wingless-related integration site (WNT) pathway [97, 98]

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