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Particular lesions presentation in the corresponding brain areas (i.e., cerebral and cerebellar cortex) likely reflect particular damaging effects (i.e., cerebellar cortex appears to be the most affected in the early course (Figure 9), cerebral cortex later less affected, microglial recruitment presented later)

and SAF2013-48983-R to I.P.-O

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Immunity 40: 692705 Nguyen A, Loo JM, Mital R, Weinberg EM, Man FY, Zeng Z, Paty PB, Saltz L, Janjigian YY, de Stanchina E, Tavazoie SF (2016a) PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis

These effects are likely due to the methylation of a CCGG site in PS1 promoter (Scarpa et al., 2003)

Pickart would spend the next 46 years expanding on that discovery (he died in 2023)