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* Correspondence: Piyush Agrawal, [email protected], [email protected] ORCID: Piyush Agrawal, orcid.org/0000-0003-2075-1111 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Melanin is what gives skin its color, and tyrosinase is the enzyme that controls the rate at which melanin is synthesized

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The ClinicalTrials.gov database (revised February 2025) (113, 114) highlights that, although numerous studies examine the impact of cholesterol-lowering drugs on cancer, only a limited number of clinical trials focus specifically on their effects on the tumor immune microenvironment

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rather, it relies on the adequate provision of biochemical precursors and cofactors required to sustain and optimize this intrinsic detoxification system