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In Japan, the rate stands at 1 in 40,000

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Sarbaziha says, this "adds another layer of risks to the drug."

Alternatively, fumaric acid can be synthesized via chemical oxidation of benzene derivatives , though fermentation-based production is preferred for food and pharmaceutical applications due to its safety profile

Side effects as nausea, diarrhea, and fishy body odor 13 were monitored

This shuttle system is critical for the production and maintenance of energy supply and is involved in the metabolic feedback regulation of respiration [5]