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Creatine is a naturally occurring compound found in muscle cells, primarily used to produce energy during high-intensity exercise

Its transmembrane domain can directly bind nonglycosylated, misfolded membrane proteins, stabilizing them until they engage canonical qualitycontrol pathways

Oltvai ZN, Milliman CL, Korsmeyer SJ

10.1007/s13311-017-0598-8 114 CristoforiF.DargenioV

For observational studies reporting serum vitamin B12 levels, the certainty of evidence was upgraded from low to moderate due to the large and consistent magnitude of effect across studies, despite heterogeneity

and 4) Oxidative stress and NO bioavailability, since age-related oxidative stress and downregulation of endothelial nitric oxide synthase (eNOS) impair the bioavailability of NO[293], which is likely to contribute to decreased microvascular density