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Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors

Its pathogenesis is not attributable to a single factor but is the result of a complex and dynamic interaction among genetic predispositions, environmental stimuli, and immune dysregulation, each of which contributes to initiating and perpetuating the disease cascade

Higher-dose oral B12 (e.g., 1000 g daily) is sometimes used but should only be considered under clinical supervision with appropriate monitoring, particularly in cases of malabsorption where intramuscular treatment remains the first-line approach in UK practice

Planta 207, 604611 (1999)

[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Kim S., Jung G., Kim S.-J., Koo J.S

3 Using pH test strips, the urinary pH of 34 healthy men and women (33.9 +/- 1.57 y, 79.3 +/- 3.1 kg) was measured for seven days to establish a baseline urinary pH without supplementation