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7.4 Limitations of current therapeutic interventions While therapeutic interventions targeting the gut-brain-metabolic axis, such as probiotics, prebiotics, dietary modifications, and FMT (Contarino et al., 2023), show promise in regulating insulin resistance and cognitive function, several limitations and unresolved issues warrant attention: 7.4.1 Variability in individual response One of the significant challenges is the variability in individual responses to these interventions (Almeida et al., 2022)