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10.1016/S0736-0266(01)00017-1 J

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

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This occurs through miR-146a upregulation, which targets and suppresses the SOCS7/JAK2-STAT3 pathway, thereby inhibiting pro-inflammatory cytokines and promoting an anti-inflammatory microenvironment

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Animal studies have shown that NAC exerts a potent protective effect against oxidative stress and inflammation under different conditions, including improvement of brain damage induced by transient cerebral ischemia [6], pain and inflammation management in case of infection [7], and restoration of thyroid morphology via reduced infiltration of inflammatory cells [8]