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362 Considering the expression of the GLP-1R in thyroid C cells and the ability of GLP-1 to stimulate calcitonin secretion through a cAMP-mediated mechanism in vitro, it is plausible that calcitonin plays a role in the alterations in bone metabolism observed in GLP-1R-treated animals

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Mast cell activation and degranulation are followed by immune activation, for instance, the recognition of LPS by toll-like receptors or by IgE receptor activation

licheniformis , Bacillus anthracis (a pathogen), and Bacillus amyloliquefaciens , and in extremophiles such as Geobacillus thermodentrificans , Deinococcus radiodurans , and Thermus thermophilus and archaea like Picrophilus torridus

Figure 1 In addition, to fully determine the impact of LA on renal dysfunction induced by FA, the direct evaluation of renal function was determined with the indicators as displayed in Supplementary Table 1, FA injection markedly decreased urine volume, glomerular filtration rate (GFR), and filtration fraction compared with control mice, but these indexes could be reversed partially by LA supplementation, without obvious difference between the two dose groups