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For example, a combination of TGF- inhibitors with PI3K/Akt pathway inhibitors could reduce myofibroblast activation and ECM production while also diminishing the survival and proliferation of this fibrotic effector cell

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The majority involve the lateral ligament complex, particularly the anterior talofibular ligament (ATFL), which sustains damage in approximately 85% of inversion injuries

3A), with Western blot confirming higher CYP3A4 expression at Day 30 compared to earlier stages (Supplementary Fig