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The compounds described are strictly intended for laboratory research and in-vitro studies only

Unlike the results found in previous studies, the effect of high dose N -acetylcysteine on air trapping and airway resistance of chronic obstructive pulmonary disease, a double-blinded, randomized, placebo-controlled trial (HIACE) conducted with 120 patients with stable COPD (58 treated with 600 mg of oral NAC twice a day and 62 with placebo), demonstrated a significant improvement in the function of the small airways, in addition to a reduction in the frequency of exacerbation of the disease [53]

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Researchers frequently include it in combination studies to observe signaling interactions or comparative pathway behavior

Conversely, patients with untreated thyroid disease, active hepatitis, or recent cardiac events should undergo comprehensive evaluation before injection therapy

Supplementary Table S2)