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Q.ZhangD.XiaoC.et al (2022)

Complementary mechanisms with GLP-1 peptides 5-amino-1mq works through a completely different pathway than GLP-1 receptor agonists like semaglutide , tirzepatide , or retatrutide

These play a significant role in neurotransmitter production, inflammation control and barrier regulation and their depletion is frequently observed in individuals with depression and anxiety further suggesting their relevance to mental health (Xiong R.-G

Hence, the overexpression of Hsa21 genes encoding proteins and non-coding RNAs (ncRNAs) could eventually disrupt several cellular functions and biological processes, thus giving rise to the different clinical conditions of DS (Antonarakis, 2017)