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For example, TLK-286 (Telcyta, canfosfamide) was identified as the lead candidate in a rationally designed series of selectively toxic glutathione analogues (Lyttle et al, 1994), which continues to be evaluated both as a single agent and in combination chemotherapy in phase II and III clinical trials in ovarian cancer and other solid tumours

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A method for inhibiting Vanin-1 in a subject in need thereof, comprising: administering the pyrimidine carboxamide compound represented by formula I, or the tautomer, mesomer, racemate, enantiomer, diastereomer thereof, or the mixture form thereof, or the pharmaceutically acceptable salt thereof according to 10

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When refrigerated, it should take on a gel-like texture
