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In many cases, profound hypotension develops intraoperatively after 45 to 60 minutes as a result of decreased vascular responsiveness and decreased myocardial contractility and is often refractory to interventions such as fluid or vasopressor therapy.8, 18, 19 Whichever surgical procedure is chosen, it is clear that anesthesia time should be minimized and long-term medical management will be necessary

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Journal of Thermal Biology, 99, 102944

Many patients report lower alcohol tolerance and more severe hangovers
