igf 1 lr3 vs igf2 lr3 IGF-1 peptide: complete guide to insulin-like growth factor for muscle growth Buy IGF-1 LR3 (1mg) |

J Respir Biol Transl Med

The mechanisms through which a low insulin drive with enhanced FoxO activation may contribute to longevity include a metabolic shift from glucose to lipid oxidation, with concomitant enhancement of cellular stress resistance and protection, suppression of inflammation and enhanced mitochondrial biogenesis (Figure 2)

[DOI] [PubMed] [Google Scholar] 87

doi: 10.1172/JCI122533 42 ZhouLZhangYMeadsMBDaiYNingYHuXet al

IGF-1 is naturally produced in the liver as a result of GH (Growth Hormone) metabolism in the presence of insulin

ET was also found to accumulate in the brain (cortex), albeit at much lower levels compared to the other organs (likely due to the slower passage through the blood brain barrier)