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The current review focuses on Se transport to the brain, including, first of all, selenoprotein P/low-density lipoprotein receptor-related protein 8 (LRP8, also known as apolipoprotein E receptor-2) dependent pathway, and supplementary transport routes of Se into the brain via low molecular weight Se-species

Gelse, K., Poschl, E

, DNA damage and repair activity after broccoli intake in young healthy smokers, Mutagenesis , vol

Because cortisol is an important regulator of redox homeostasis, reduced cortisol availability or altered glucocorticoid signaling may weaken anti-inflammatory and antioxidant defenses, thereby contributing to persistent oxidative stress

IR impairs mitochondrial substrate utilization, shifting energy metabolism from glucose oxidation toward fatty acid oxidation, which increases ROS production and reduces oxidative phosphorylation efficiency

In conclusion, the in vivo work on Gstp / mice fully demonstrates that GSTP acts as a negative regulator in sepsis pathophysiology, and recombinant GSTP protein treatment to mice may significantly improve survival in mouse CLP sepsis model