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Maintenance injections are generally taken once absorption from the previous dose begins to taper off, around 4-6 weeks later

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doi: 10.1371/journal.pbio.3001948 312

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Additional immunofluorescence (IF) images with marked regions of interest (ROI) are provided in Supplementary Figure S3A-S3D

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Hyperglycemia-induced interactions between AGEs and their receptor, receptor for advanced glycation end products (RAGE), activate NF-B signaling in renal macrophages, thereby amplifying pro-inflammatory cytokines and chemokines that recruit monocytes to the kidney

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